Human Oral Microbiome Taxon Description
Treponema denticola
Human Oral Taxon ID (HOT):584Synonym:
Status:
Named - Cultured
Type Strain:
ATCC 35405
More info at StrainInfo
Classification:
Domain:Bacteria
Phylum:Spirochaetes
Class:Spirochaetia
Order:Spirochaetales
Family:Spirochaetaceae
Genus:Treponema
Species:denticola
NCBI Taxonomy ID:
16S rRNA Sequence:
M71236  [Entrez Link]
PubMed Search:1133  [PubMed Link]
16S rRNA Alignment: View Alignment         Download Alignment         NoteNucleotide Search:1518  [Entrez Nucleotide Link]
Phylogeny: View 16S rRNA tree         View all Tree filesProtein Search:69234  [Entrez Protein Link]
Prevalence by Molecular Cloning:
Clones seen = 77 / 34879 = 0.221%
Rank Abundance = 90
Genome Sequence
17 View Genomes
 
Hierarchy Structure:    Hide or show the hierarchy structure
General Information:
T. denticola is a member of Group II, o­ne of the 10 phylogenetic groups of oral treponemes [1,2]. 
Cultivability:
Anaerobic growth in peptone-yeast extract, serum containing medium.  White, diffuse colonies (0.3 to 1 mm) in diameter o­n solid media after 2 weeks incubation.
Phenotypic Characteristics:
Obligately anaerobic, catalase negative, helically coiled with translational motility.  Will creep o­n solid surfaces, such as agar media or glass.  Cells are Gram-negative,  0.2 um by 6-16  um, with a 2-4-2 periplasmic flagellar arrangement. G+C content is 37-38 mol%

Ferments amino acids (alanine, cysteine, glycine and serine) with acetate as the major endproduct, with lesser amounts of lactic acid, succinic acid and formic acid.   Ammonia is produced from amino acids. Arginine can serve as an energy source.  Glucose can be degraded using the Embden-Meyerhof pathway [3], but not by the glycolytic pathway.   Strains are resistant to rifampicin.

Prevalence and Source:
Frequently isolated from human subgingival plaque, especially from subjects with periodontitis.  Reported to be present in chimpanzees
Disease Associations:
Known as a member of the "red complex" and is strongly associated with periodontal disease [4].  Also associated with endodontic lesions.
References:
PubMed database:
[1] Chan EC, Siboo R, Keng T, Psarra N, Hurley R, Cheng SL, Iugovaz I. Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets. Int J Syst Bacteriol. 1993 Apr;43(2):196-203  [PubMed]
[2] Dewhirst FE, Tamer MA, Ericson RE, Lau CN, Levanos VA, Boches SK, Galvin JL, Paster BJ. The diversity of periodontal spirochetes by 16S rRNA analysis. Oral Microbiol Immunol. 2000 Jun;15(3):196-202  [PubMed]
[3] Hespell RB, Canale-Parola E. Amino acid and glucose fermentation by Treponema denticola. Arch Mikrobiol. 1971;78(3):234-51  [PubMed]
[4] Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb;25(2):134-44  [PubMed]
   
Curator:  
Creation Info:   Latest Modification:  abby,  2009-09-08 15:50:38

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