Human Oral Microbiome Taxon Description
Prevotella intermedia
Human Oral Taxon ID (HOT):643Synonym:
Bacteroides intermedius
Bacteroides melaninogenicus
Named - Cultured
Type Strain:
ATCC 25611
More info at StrainInfo
NCBI Taxonomy ID:
16S rRNA Sequence:
L16468  [Entrez Link]
PubMed Search:1567  [PubMed Link]
16S rRNA Alignment: View Alignment         Download Alignment         NoteNucleotide Search:406  [Entrez Nucleotide Link]
Phylogeny: View 16S rRNA tree         View all Tree filesProtein Search:8676  [Entrez Protein Link]
Prevalence by Molecular Cloning:
Clones seen = 55 / 34879 = 0.158%
Rank Abundance = Tied for 116
Genome Sequence
2 View Genomes
Hierarchy Structure:    Hide or show the hierarchy structure
General Information:
Formerly known as Bacteroides melaninogenicus subsp. intermedius, and then Bacteroides intermedius.   Phylogenetic analysis based o­n 16S rRNA sequence comparisons and biochemical characteristics warranted separate genus designation to the genus Prevotella, i.e., Prevotella intermedia [1].
Black pigmented colonies (0.5- 2.0 mm diameter) after anaerobic incubation for 2 days o­n hemin-containing agar media.  Hemin is required for growth, Vitamin K is stimulatory.  Colonies fluoresce under shortwave UV.
Phenotypic Characteristics:
Obligately anaerobic, Gram negative, short rod (0.5 by 2 um). Moderately saccaharolytic, fermenting glucose and other carbohydrates to mainly to succinate and acetate. Cell walls contain meso-diaminopimelic acid, but not KDO or heptose.
Prevalence and Source:

Primarily colonizes the gingival crevice, but also found in head, neck, abdominal, and lung infections.  Has been isolated from blood.

Disease Associations:

Although commonly detected in subgingival plaque, P. intermedia has been associated with periodontal disease [2], aggressive periodontitis, necrotizing ulcerative periondontis, endodontic  infections [4], and facial gangrene (noma) [5].  Has also been linked to coronary artery disease [3].

PubMed database:
[1] Shah HN, Collins DM. Prevotella, a new genus to include Bacteroides melaninogenicus and related species formerly classified in the genus Bacteroides. Int J Syst Bacteriol. 1990 Apr;40(2):205-8  [PubMed]
[2] Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb;25(2):134-44  [PubMed]
[3] Nonnenmacher C, Stelzel M, Susin C, Sattler AM, Schaefer JR, Maisch B, Mutters R, Flores-de-Jacoby L. Periodontal microbiota in patients with coronary artery disease measured by real-time polymerase chain reaction: a case-control study. J Periodontol. 2007 Sep;78(9):1724-30  [PubMed]
[4] Gomes BP, Jacinto RC, Pinheiro ET, Sousa EL, Zaia AA, Ferraz CC, Souza-Filho FJ. Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia and Prevotella nigrescens in endodontic lesions detected by culture and by PCR. Oral Microbiol Immunol. 2005 Aug;20(4):211-5  [PubMed]
[5] Enwonwu CO, Falkler WA, Idigbe EO. Oro-facial gangrene (noma/cancrum oris): pathogenetic mechanisms. Crit Rev Oral Biol Med. 2000;11(2):159-71  [PubMed]
Creation Info:   Latest Modification:  abby,  2009-09-08 12:45:57

Copyright 2007-2016 The Forsyth Institute