16S rRNA Refseq V15.22 Genomic RefSeq V9.14
Human Oral Microbiome Taxon Description
Treponema lecithinolyticum
Human Microbial Taxon ID:653Body Site:Oral
Status:
Named - Cultured
Synonym:
Treponema sp. IV:17C:GF6
Strain Information:
ATCC 700332, OMZ 684
Check Global Catalogue of Microorganisms
Classification:
Domain:Bacteria
Phylum:Spirochaetes
Class:Spirochaetia
Order:Spirochaetales
Family:Spirochaetaceae
Genus:Treponema
Species:lecithinolyticum
NCBI Taxonomy ID:
16S rRNA Reference Sequences:
HOMD RefSeq ID: 653_3040

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PubMed Search:15  [PubMed Link]
Nucleotide Search:114  [Entrez Nucleotide Link]
Protein Search:4359  [Entrez Protein Link]
Abundance:
By molecular cloning:
Clones seen = 13 / 34879 = 0.0373%
Rank Abundance = Tied for 244
In other datasets:
TBD
Genome Sequence
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General Information:
Member of o­ne of the 10 phylogenetic groups of oral treponemes [1,4]. Originally detected in subjects with periodontitis as not-yet-cultivated phylotype (Group IV) termed Treponema sp. IV:17C:GF6 [4].  Closest cultivable relative is Treponema maltophilum, which also falls in Group IV.
Cultivability:
Growth o­n OMIZ-Pat-w/oPC agarose [1], are off-white, diffuse (~3 mm), subsurface colonies after 7 days incubation at 37oC.  Will not grow in chemically defined media, e.g., OMIZ-W1 [1], but requires yeast extract or Neopeptone
Phenotypic Characteristics:
Obligately anaerobic, catalase negative, helically coiled with translational motility in broth, especially in media of high viscosity [1].  Will creep o­n solid surfaces, such as agar media or glass.  Cells are Gram-negative,  0.15 um by 5 um, with a 1-2-1 periplasmic flagellar arrangement.

N-acetylglucosamine is required for growth, and D-arabinose, L-fucose or D-ribose enhance growth.  Other carbohydrates do not appear to support growth. Lecithin and 1% fetal calf serum inhibits growth.  Strains are resistant to rifampicin and fosfomycin.

High activities for alkaline phosphatase, acid phosphatase, B-galactosidase, B-glucuronidase, N-acetyl-B-glucosaminidase, phospholipase A, and phospholipase C
Prevalence and Source:

Detected in human subgingival plaque, most often in subjects with periodontitis

Disease Associations:
Association (e.g. diseased vs control sites) in patients with adult periodontitis and rapidly progressive periodontitis [1,3] and endodontic lesions [2].  Strong activities of phospholipase A and phospholipase C may serve as potential virulence factors [1]
References:
PubMed database:
[1] Wyss C, Choi BK, Schüpbach P, Moter A, Guggenheim B, Göbel UB. Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases. Int J Syst Bacteriol.1999 Oct;49 Pt 4:1329-39  [PubMed]
[2] Siqueira JF Jr, Rôças IN. PCR-based identification of Treponema maltophilum, T amylovorum, T medium, and T lecithinolyticum in primary root canal infections. Arch Oral Biol.2003 Jul;48(7):495-502  [PubMed]
[3] Moter A, Riep B, Haban V, Heuner K, Siebert G, Berning M, Wyss C, Ehmke B, Flemmig TF, Göbel UB. Molecular epidemiology of oral treponemes in patients with periodontitis and in periodontitis-resistant subjects. J Clin Microbiol.2006 Sep;44(9):3078-85  [PubMed]
[4] Dewhirst FE, Tamer MA, Ericson RE, Lau CN, Levanos VA, Boches SK, Galvin JL, Paster BJ. The diversity of periodontal spirochetes by 16S rRNA analysis. Oral Microbiol Immunol.2000 Jun;15(3):196-202  [PubMed]
   
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Creation Info:   Latest Modification:  wenhan,  2008-04-10 11:58:57
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