Human Oral Microbiome Taxon Description
Streptococcus sanguinis
Human Oral Taxon ID (HOT):758Synonym:
Streptococcus sanguinis
Streptococcus sanguis ss. carlssonii
Named - Cultured
Type Strain:
ATCC 10556, NCTC7863
More info at StrainInfo
NCBI Taxonomy ID:
16S rRNA Sequence:
AF003928  [Entrez Link]
PubMed Search:303  [PubMed Link]
16S rRNA Alignment: View Alignment         Download Alignment         NoteNucleotide Search:2034  [Entrez Nucleotide Link]
Phylogeny: View 16S rRNA tree         View all Tree filesProtein Search:84592  [Entrez Protein Link]
Prevalence by Molecular Cloning:
Clones seen = 851 / 34879 = 2.44%
Rank Abundance = 4
Genome Sequence
13 View Genomes
Hierarchy Structure:    Hide or show the hierarchy structure
General Information:
Viridans type of streptococci has had taxonomic revisions [1,5].    Previously designated as strains of Streptococcus sanguis subsp. carlssonii.  Will also see in the literature as Streptococcus sanguinis, a proposed name change.  
Alpha-hemolytic colonies (0.7- 1.2 mm diameter) o­n blood agar and extensive greening o­n chocolate agar [5,6]. 
Phenotypic Characteristics:
Facultatively anaerobic, Gram positive cocci, approximately 1 um in diameter, that grow in short chains in broth cultures.   Carbohydrates are femented primarily to lactic acid and no gas. Catalase negative.  Cell wall contains glycerol teichoic acid and rhamnose. Peptidoglycan type is Lys-Ala1-3 [5,6]

S. sanguis is similar to S. gordonii but can be differentiated based o­n the following; DNA homology, higher G+C content of the DNA (46  vs 42 mol%), doesn't ferment amygdalin, lacks alkaline phosphatase and B-glucosaminidase activities, has IgA1 protease activity, and by multilocus enzyme analysis [5,6].

4 biovars of S. sanguis differ biochemically and serologically, but all biovars possess the group H antigen [5]
Prevalence and Source:
Commonly found in the human oral cavity and throat.  Has been isolated from blood and heart valves of patients with bacterial endocarditis.  May be found occasionally in human feces
Disease Associations:
Generally associated with healthy oral microflora, but has been associated with intact enamel in children with no caries [2].  However, it has been suggested that it may play a role in caries production [3].

Has also been associated with infective endocarditis and sinusitis.  S. sanguis and other oral species have been linked to Behcet's disease, a systemic disorder of recurrent acute inflammation, including oral aphthous ulcers, uveitis, skin lesions and genital ulcers [4]
PubMed database:
[1] Coykendall AL, Specht PA. DNA base sequence homologies among strains of Streptococcus sanguis. J Gen Microbiol. 1975 Nov;91(1):92-8  [PubMed]
[2] Becker MR, Paster BJ, Leys EJ, Moeschberger ML, Kenyon SG, Galvin JL, Boches SK, Dewhirst FE, Griffen AL. Molecular analysis of bacterial species associated with childhood caries. J Clin Microbiol. 2002 Mar;40(3):1001-9  [PubMed]
[3] Sansone C, Van Houte J, Joshipura K, Kent R, Margolis HC. The association of mutans streptococci and non-mutans streptococci capable of acidogenesis at a low pH with dental caries on enamel and root surfaces. J Dent Res. 1993 Feb;72(2):508-16  [PubMed]
[4] Suzuki Kurokawa M, Suzuki N. Behcet's disease. Clin Exp Med. 2004 Sep;4(1):10-20  [PubMed]
Non-PubMed database:
[5] Kilian M, Mikkelsen L, Henrichsen J. Taxonomic study of viridans Streptococci: Description of Streptococcus gordonii sp. nov. and emended descriptions of S. sanguis (White and Niven 1946), S. oralis .... Int J Syst Bacteriol. 1989 Oct;39(4):471-84.  
[6] Hardie RM. Genus Streptococcus. Bergey's Manual of Systematic Bacteriology 1986; Vol. 2, pp. 1043-1063.  
Creation Info:   Latest Modification:  wenhan,  2008-01-15 14:24:44

Copyright 2007-2016 The Forsyth Institute